I often do a draft when I play: deal out 10 randomizer cards, then you go around the table and each player chooses a card, then either puts it in the supply or vetos it. Either way, you deal out a new card to replace it. With four people, you go around twice; after the last pick, you shuffle the remaining randomizers and deal out as many as you need to reach 10.
Or, for a real crazy and probably hideously unbalanced game, just take one of each card, shuffle them up and divide them into 10 piles, and just use that as your Supply. You'll probably want to put all the cards that cost a Potion in their own pile, or else just not use them at all.