With Witch and Chapel on the board, Familiar seems like a slow bet. I would open Chapel/Cutpurse and then try to get Festival and Wharf. Once you have Festival/Wharf going, you won't have trouble trashing incoming Curses, so I would only get Witch if the opponents won't be dealing with Curses effectively. If they are already Cursing each other, all the better. In case of terminal collision, prioritze Chapelling, because Curses snowball so its important to mantain a thin deck to keep up. There is also material for double-Tactitian, although I feel like Wharf already draws pretty well and is faster to set up and better to Attack while setting up. Get the Attack that the others do not get, so if everyone is Cursing, get Cutpurse and possibly Ghost Ship (if you manage to get enough Festivals). If nobody else is giving out Curses, get your own. You can even add Festival later if it seems appropiate, but at the beginning is more important to focus on trashing, Festivals (because they will run out) and Wharves (because they accelerate you a lot). Familiar may be a good option if there is little Cursing from opponents and you do not have enough Festivals to manage another terminal.